Moral Molecules, Modern Selves, and Our "Inner Tribe"

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The Hybrid Hominin: A Renewed Point of Departure For Philosophical Anthropology.

Chapter 7 of forthcoming book "Naturalism and Philosophical Anthropology: Nature, Life and the Human Between Transcendental and Empirical Perspectives" to be published by Palgrave Macmillan and reproduced with permission of Palgrave Macmillan. This extract is taken from the author's original manuscript and has not been edited. The definitive, published, version of record will be available when published at www.palgrave.com and www.palgraveconnect.com.The goal of this paper will be nothing short of offering a new point of departure for philosophical anthropology (and thereby for philosophy and the human sciences in general). The crux of this effort will be developed around a novel concept of the ‘Hybrid Hominin’ and an exploration of its descriptive and normative implications. The intentions will not be to jettison prior insights from philosophical anthropology but rather to recontextualize them in a way that both preserves and yet further mobilizes their insights. Indeed the very measure of the success of this enterprise will be precisely its ability to bring the legacy of philosophical anthropology to further fruition and in the context of dialogues with some of the contributors to this valuable new collection

The Question of Questions: What is a Gene? Comments on Rolston and Griffths & Stotz

If the question “What is a gene?” proves to be worth asking it must be able to elicit an answer which both recognizes and address the reasons why the concept of the gene ever seemed to be something worth getting excited about in the first place as well analyzing and evaluating the latest develops in the molecular biology of DNA. Each of the preceding papers fails to do one of these and sufferrs the consequences. Where Rolston responds to the apparent failure of molecular biology to make good on the desideratum of the classical gene by veering off into fanciful talk about “cybernetic genes,” Griffiths and Stotz lose themselves in the molecular fine print and forget to ask themselves why “genes” should be of any special interst anyway

Genes in the postgenomic era

We outline three very different concepts of the gene - 'instrumental', 'nominal', and 'postgenomic'. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype is explored via hybridization between organisms or directly between nucleic acid molecules. It also plays an important theoretical role in the foundations of disciplines such as quantitative genetics and population genetics. The nominal gene is a critical practical tool, allowing stable communication between bioscientists in a wide range of fields grounded in well-defined sequences of nucleotides, but this concept does not embody major theoretical insights into genome structure or function. The post-genomic gene embodies the continuing project of understanding how genome structure supports genome function, but with a deflationary picture of the gene as a structural unit. This final concept of the gene poses a significant challenge to conventional assumptions about the relationship between genome structure and function, and between genotype and phenotype

Adapting to deficiency : addiction and the therapeutic power of occupation

Occupational therapy (OT) has been greatly influenced by the medical model, despite its origins as an alternative to medicine. OT practice that finds its theoretical basis in a medical model is criticized as limited in therapeutic value, and as lacking boundaries distinguishing OT from other disciplines. By advancing a philosophical anthropology (Gehlen) with biological evidence from detachment theory (Moss), this project identifies and illuminates the power and unique value of occupational therapy. Occupational participation, made possible by OT, is described as a tool for structuring human lives into manageable temporal components with varying degrees of motivation and social interconnection. The value of providing opportunities for occupational participation is described as analogous to the value of instincts in animals’ lives; occupations are seen as the core elements that drive and shape human experiences. The inadequacies of current definitions of and research on addiction are reviewed and, as an alternative to current approaches, an occupational model for understanding addiction is outlined. Addiction is described as an attempt to create a manageable life—that is, as an occupation, and the concept of focused flexibility is introduced to normatively distinguish ‘addiction-occupations’ from other, potentially more ‘healthy’ occupations. Health is discussed in relation to the proposed philosophical anthropological, social, and biological situation of human beings. Finally, a qualitative study is undertaken to examine whether an occupational model of addiction accurately describes the experiences of addicts, thereby warranting further research. Findings from this preliminary study suggest addiction is experienced as an occupation, and that the concept of addiction as an occupation should be further explored.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Adapting to deficiency : addiction and the therapeutic power of occupation

Occupational therapy (OT) has been greatly influenced by the medical model, despite its origins as an alternative to medicine. OT practice that finds its theoretical basis in a medical model is criticized as limited in therapeutic value, and as lacking boundaries distinguishing OT from other disciplines. By advancing a philosophical anthropology (Gehlen) with biological evidence from detachment theory (Moss), this project identifies and illuminates the power and unique value of occupational therapy. Occupational participation, made possible by OT, is described as a tool for structuring human lives into manageable temporal components with varying degrees of motivation and social interconnection. The value of providing opportunities for occupational participation is described as analogous to the value of instincts in animals’ lives; occupations are seen as the core elements that drive and shape human experiences. The inadequacies of current definitions of and research on addiction are reviewed and, as an alternative to current approaches, an occupational model for understanding addiction is outlined. Addiction is described as an attempt to create a manageable life—that is, as an occupation, and the concept of focused flexibility is introduced to normatively distinguish ‘addiction-occupations’ from other, potentially more ‘healthy’ occupations. Health is discussed in relation to the proposed philosophical anthropological, social, and biological situation of human beings. Finally, a qualitative study is undertaken to examine whether an occupational model of addiction accurately describes the experiences of addicts, thereby warranting further research. Findings from this preliminary study suggest addiction is experienced as an occupation, and that the concept of addiction as an occupation should be further explored.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The grassblade beyond Newton: self-organizing matter and the pragmatizing of Kant for evolutionary-developmental biology

ArticleMuch of the philosophical attention directed to Kant’s intervention into biology has been directed toward Kant’s idea of a transcendental limit upon what can be understood constitutively. Kant’s own wider philosophical practice, however, was principally oriented toward solving problems and the scientific benefits of his methodology of teleology have been largely underappreciated, at least in the English language literature. This paper suggests that all basic biology has had, and continues to have, a need for some form of heuristic “bracketing” and that a renewal of some form of, albeit flexible, teleological methodological bracketing can better complement the productive assimilation into developmental biology of continuing advances in our understanding of the mesoscale physics and chemistry of soft, excitable condensed matter, than what has been the prevailing and de facto use of a form of bracketing shaped by the neoDarwinian Modern Synthesis. Further we offer a concept of biogeneric processes and a framework of physico-genetic “dynamical patterning modules”, that can begin to account for the appearance of new Kantian “stocks of Keime und Anlagen”, capable of potentiating some range of possible organismal forms, and provide grounds for moving up the teleological “goalposts”, i.e., expanding the range of what can be accounted for on a constitutive basis

Biology and ontology : an organism-centred view

In this dissertation I criticize and reconfigure the ontological framework within which discussions of the organization, ontogeny, and evolution of organic form have often been conducted. Explanations of organismal form are frequently given in terms of a force or essence that exists prior to the organism’s life in the world. Traits of organisms are products of the selective environment and the unbroken linear inheritance of genetically coded developmental programs. Homological traits share unbroken vertical inheritance from a single common ancestor. Species are the product of exclusive gene flow between conspecifics and vertical genetic inheritance. And likewise, race is ascribed on the basis of pre-existing essential features. In place of this underlying preformationism which locates the source of form either in the informational program of inherited genes or within a selecting environment, I suggest form is the product of an organism’s self-construction using diverse resources. This can be understood as a modification of Kant’s view of organisms as self-organizing, set out in his Critique of Judgment (1790). Recast from this perspective the meaning and reference of “trait,” “homology,” “species,” and “race” change. Firstly, a trait may be the product of the organism’s self-construction utilizing multiple ancestral resources. Given this, homologous traits may correspond in some but not all of their features or may share some but not all of their ancestral sources. Homology may be partial. Species may acquire epigenetic, cellular, behavioural, and ecological resources both vertically and horizontally. As such, they are best conceived of as recurrent successions of self-constructed and reconstructed life cycles of organisms sharing similar resources, a similar habitus, similar capacities for sustaining themselves, and repeated generative processes. Lastly, race identity is not preformed but within the control of human organisms as agents who self-construct, interpret, and ascribe their own race identities utilizing diverse sets of dynamic relationships, lived experiences, and histories.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Organism and mechanism : a critique of mechanistic thinking in biology

In this thesis I present a critical examination of the role played by mechanistic ideas in shaping our understanding of living systems. I draw on a combination of historical, philosophical, and scientific resources to uncover a number of problems which I take to result from the adoption of mechanistic thinking in biology. I provide an analysis of the historical development of the conflict between mechanistic and vitalistic conceptions of life since the seventeenth century, and I argue that the basic terms of this conflict remain central to current disputes over the nature of the organism as well as the question of how far the theories, concepts, and methods of physics, chemistry, and engineering can ultimately take us in the explanation of life. I offer a detailed critique of the machine conception of the organism, which constitutes the central unifying idea of mechanistic biology. I argue that this notion, despite its undeniable heuristic value, is fundamentally inadequate as a theory of the organism due to a number of basic differences between organisms and machines. Ultimately, I suggest that the neglected vitalistic tradition in biology actually possesses the best conceptual tools for coming to terms with the nature of living systems. I also undertake a philosophical analysis of the concept of mechanism in biology. I argue that the term ‘mechanism’ is actually an umbrella term for three distinct notions, which are unfortunately conflated in philosophical discussions. I explore the relation between mechanistic biology and the new philosophical interest in the concept of mechanism and I show that these two research programs have little to do with one another because each of them understands the concept of mechanism in a different way. Finally, I draw on the historical and philosophical foundations of cell theory to propose an epistemological perspective which enables the reductionistic explanation of the organism without having to give up the distinctive features of life in the process. In this way, I show this perspective to have significant advantages over the classic physicochemical reductionism of mechanistic biology.EThOS - Electronic Theses Online ServiceDepartment of Sociology and Philosophy, University of ExeterGBUnited Kingdo